Inhibitory constituents against HIV-1 protease from Agastache rugosa

Arch Pharm Res. 1999 Feb;22(1):75-7. doi: 10.1007/BF02976440.

Abstract

Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with IC50 values of 360 and 87 microM, respectively.

MeSH terms

  • Abietanes*
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology
  • HIV Protease / metabolism*
  • HIV Protease Inhibitors / isolation & purification*
  • HIV Protease Inhibitors / pharmacology
  • Humans
  • Lamiaceae / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Spectrophotometry, Ultraviolet

Substances

  • Abietanes
  • Diterpenes
  • HIV Protease Inhibitors
  • Plant Extracts
  • agastanol
  • agastaquinone
  • HIV Protease