Xenopus axin interacts with glycogen synthase kinase-3 beta and is expressed in the anterior midbrain

Mech Dev. 1999 Feb;80(2):147-51. doi: 10.1016/s0925-4773(98)00203-2.

Abstract

Axin is encoded by the fused locus in mice and is required for normal vertebrate axis formation. It has recently been shown that axin associates with APC, beta-catenin and glycogen synthase kinase-3 (GSK-3) in a complex that appears to regulate the level of cytoplasmic beta-catenin. We have identified the Xenopus homologue of axin through its interaction with GSK-3b. Xenopus axin (Xaxin) is expressed maternally and throughout early development with a low level of ubiquitous expression. Xaxin also shows remarkably high expression in the anterior mesencephalon adjacent to the forebrain-midbrain boundary.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Axin Protein
  • Calcium-Calmodulin-Dependent Protein Kinases / metabolism*
  • Glycogen Synthase Kinase 3
  • Glycogen Synthase Kinases
  • In Situ Hybridization, Fluorescence
  • Mesencephalon / metabolism*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / metabolism*
  • Proteins / genetics
  • Proteins / metabolism*
  • Repressor Proteins*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Xenopus Proteins
  • Xenopus laevis / genetics
  • Xenopus laevis / metabolism*

Substances

  • Axin Protein
  • Nerve Tissue Proteins
  • Proteins
  • Repressor Proteins
  • Xenopus Proteins
  • axin1 protein, Xenopus
  • Glycogen Synthase Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Glycogen Synthase Kinase 3

Associated data

  • GENBANK/AF097313