Abstract
Bioassay-guided fractionation of the EtOH extract of M. africana, using the in vivo noninsulin-dependent diabetes mellitus db/db mouse model, resulted in the isolation of the new daphnane-type diterpenoid maprouneacin (2). Compound 2 showed potent glucose-lowering properties when given by the oral route.
MeSH terms
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Animals
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Blood Glucose / analysis
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Body Weight / drug effects
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Diabetes Mellitus, Type 2 / drug therapy*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Diterpenes / therapeutic use*
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Feeding Behavior / drug effects
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology
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Hypoglycemic Agents / therapeutic use*
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Mice
Substances
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Blood Glucose
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Diterpenes
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Hypoglycemic Agents
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maprouneacin