Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system

Brain Res Mol Brain Res. 1999 Mar 20;66(1-2):205-10. doi: 10.1016/s0169-328x(99)00036-4.

Abstract

Recent cloning studies have isolated proteins which confer responsiveness to calcitonin gene-related peptide (CGRP). In this study, we have determined the central nervous system (CNS) distribution of the mRNA of one such protein, termed CGRP-receptor component protein (RCP), by in situ hybridization. CGRP-RCP mRNA was widely expressed in the guinea-pig CNS, being particularly abundant in cerebellum and hippocampus. These data should assist in the determination of the potential physiological function(s) of this protein in the CNS.

MeSH terms

  • Animals
  • Brain Chemistry / genetics*
  • Central Nervous System / chemistry
  • Central Nervous System / physiology
  • Gene Expression / physiology
  • Guinea Pigs
  • In Situ Hybridization
  • Iodine Radioisotopes
  • Male
  • Oligonucleotide Probes
  • RNA, Messenger / analysis
  • Receptors, Calcitonin Gene-Related Peptide / genetics*

Substances

  • Iodine Radioisotopes
  • Oligonucleotide Probes
  • RNA, Messenger
  • Receptors, Calcitonin Gene-Related Peptide