Abstract
The hemostimulating activity of the drug glycyrram and the recombinant granulocytic-macrophagic colony-stimulating factor (CSF) was compared on models of myelosuppression induced by injection of an alkylating agent cyclophospane (CF) or the antimetabolite 5-fluorouracil (5-FU). It was found that glycerram stimulated hematopoiesis more effectively after 5-FU injection but to a lesser extent (in relation to CSF) in CF injection.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Animals
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Antimetabolites, Antineoplastic / pharmacology
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Antineoplastic Agents / pharmacology*
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Antineoplastic Agents, Alkylating / pharmacology
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Bone Marrow / drug effects*
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Colony-Forming Units Assay / statistics & numerical data
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Cyclophosphamide / pharmacology
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Depression, Chemical
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Fluorouracil / pharmacology
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Glycyrrhetinic Acid / pharmacology*
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Granulocyte-Macrophage Colony-Stimulating Factor / pharmacology*
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Hematopoiesis / drug effects*
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Mice
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Mice, Inbred CBA
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Recombinant Proteins
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Stimulation, Chemical
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Time Factors
Substances
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Antimetabolites, Antineoplastic
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Antineoplastic Agents
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Antineoplastic Agents, Alkylating
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Recombinant Proteins
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Granulocyte-Macrophage Colony-Stimulating Factor
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Cyclophosphamide
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Glycyrrhetinic Acid
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Fluorouracil