Studies of antibacterial activity of binuclear rhodium (II) complexes with heterocyclic nitrogen ligands

J Inorg Biochem. 1999 Jan-Feb;73(1-2):49-55. doi: 10.1016/s0162-0134(98)10090-9.

Abstract

Binuclear rhodium (II) complexes, [Rh2(OOCPh)2(phen)2(H2O)2] (OOCPh)2 (1), [Rh2(OOCPh)2(bpy)2(H2O)2] (OOCPh)2 (2), [Rh2(OOCBu(n))2 (bpy)2(H2O)2] (OOCBu(n)2 (3), and [Rh2(OOCPr(n)2 (phen)2(H2O)2] (OOCPr(n)2 (4) (Phen = 1,10-phenanthroline and bpy = 2,2'-bipyridine), have been synthesized and characterized using NMR, IR and electronic spectra. Activity of these compounds against Gram-positive bacteria decreases in the order: 1?2?3 > 4. Complex 1 is active against many Staphylococcus strains resistant to commonly used antibiotics. The complexes 1-4 are much less active agents against Gram-negative bacteria.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Gram-Negative Bacteria / drug effects
  • Gram-Positive Bacteria / drug effects
  • Heterocyclic Compounds / chemistry*
  • Light
  • Microbial Sensitivity Tests
  • Nitrogen / chemistry*
  • Rhodium / chemistry
  • Rhodium / pharmacology*
  • Species Specificity
  • Spectrum Analysis

Substances

  • Anti-Bacterial Agents
  • Heterocyclic Compounds
  • Rhodium
  • Nitrogen