Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus

B S Yun; I J Ryoo; I K Lee; K H Park; D H Choung; K H Han; I D Yoo

doi:10.1021/np9804637

Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus

J Nat Prod. 1999 May;62(5):764-6. doi: 10.1021/np9804637.

Authors

B S Yun¹, I J Ryoo, I K Lee, K H Park, D H Choung, K H Han, I D Yoo

Affiliation

¹ Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.

PMID: 10346965
DOI: 10.1021/np9804637

Abstract

Two new triterpene caffeates have been isolated from the root bark of Hibiscus syriacus. Their structures were established through various spectral studies as 3beta,23,28-trihydroxy-12-oleanene 23-caffeate (1) and 3beta,23,28-trihydroxy-12-oleanene 3beta-caffeate (2). Compounds 1 and 2 showed lipid peroxidation inhibitory activity and significant cytotoxicity against a panel of human cancer cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Antioxidants / chemistry
Antioxidants / isolation & purification*
Antioxidants / pharmacology
Drug Screening Assays, Antitumor
Humans
Lipid Peroxidation / drug effects
Magnetic Resonance Spectroscopy
Malvaceae / chemistry*
Plant Roots / chemistry
Spectrometry, Mass, Fast Atom Bombardment
Triterpenes / chemistry
Triterpenes / isolation & purification
Triterpenes / pharmacology*
Tumor Cells, Cultured

Substances

3,23,28-trihydroxy-12-oleanene 23-caffeate
Antineoplastic Agents, Phytogenic
Antioxidants
Triterpenes