Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

Y Namba; Y Ouchi; A Takeda; A Ueki; K Ikeda

doi:10.1016/s0006-8993(99)01435-3

Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

Brain Res. 1999 May 29;830(1):200-2. doi: 10.1016/s0006-8993(99)01435-3.

Authors

Y Namba¹, Y Ouchi, A Takeda, A Ueki, K Ikeda

Affiliation

¹ Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. ynanba-tky@umin.ac.jp

PMID: 10350576
DOI: 10.1016/s0006-8993(99)01435-3

Abstract

Bleomycin hydrolase (BH), a cysteine protease belonging to the papain superfamily, is one of the candidate beta secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / enzymology*
Alzheimer Disease / pathology
Case-Control Studies
Cysteine Endopeptidases / analysis*
Humans
Immunohistochemistry
Plaque, Amyloid / enzymology*

Substances

Cysteine Endopeptidases
bleomycin hydrolase