A thioester analogue of an amino acetylenic aldehyde is a suicide inhibitor of aldehyde dehydrogenase and an inducer of apoptosis in mouse lymphoid cells overexpressing the bcl2 gene

Adv Exp Med Biol. 1999:463:97-106. doi: 10.1007/978-1-4615-4735-8_12.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehyde Dehydrogenase / antagonists & inhibitors*
  • Aldehydes / chemical synthesis
  • Aldehydes / metabolism*
  • Animals
  • Apoptosis*
  • Cell Line
  • DNA Fragmentation
  • Enzyme Inhibitors / metabolism*
  • Gene Expression
  • Growth Inhibitors / pharmacology
  • HeLa Cells
  • Humans
  • Lymphocytes / cytology
  • Lymphocytes / metabolism
  • Mice
  • Proto-Oncogene Proteins c-bcl-2 / biosynthesis*
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Saccharomyces cerevisiae
  • Sulfhydryl Compounds / metabolism*

Substances

  • Aldehydes
  • Enzyme Inhibitors
  • Growth Inhibitors
  • Proto-Oncogene Proteins c-bcl-2
  • Sulfhydryl Compounds
  • methional
  • 4-amino-4-methyl-2-pentyne-1-al
  • Aldehyde Dehydrogenase