Mapping of semantic, phonological, and orthographic verbal working memory in normal adults with functional magnetic resonance imaging

Neuropsychology. 1999 Apr;13(2):171-87. doi: 10.1037//0894-4105.13.2.171.

Abstract

Twelve neurologically normal participants (4 men and 8 women) performed semantic, phonological, and orthographic working memory tasks and a control task during functional magnetic resonance imaging. Divergent regions of the posterior left hemisphere used for decoding and storage of information emerged in each working memory versus control task comparison. These regions were consistent with previous literature on processing mechanisms for semantic, phonological, and orthographic information. Further, working memory versus control task differences extended into the left frontal lobe, including premotor cortex, and even into subcortical structures. Findings were consistent with R. C. Martin and C. Romani's (1994) contention that different forms of verbal working memory exist and further suggest that a reconceptualization of premotor cortex functions is needed.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Brain Mapping / methods*
  • Dominance, Cerebral / physiology
  • Female
  • Frontal Lobe / anatomy & histology*
  • Frontal Lobe / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging / methods*
  • Male
  • Memory, Short-Term / classification
  • Memory, Short-Term / physiology*
  • Prefrontal Cortex / anatomy & histology
  • Prefrontal Cortex / physiology
  • Psycholinguistics / methods*
  • Psychomotor Performance / physiology
  • Reference Values
  • Verbal Learning / physiology*
  • Word Association Tests