Chemokine receptors in lymphoid organ homeostasis

S Jung; D R Littman

doi:10.1016/s0952-7915(99)80051-x

Chemokine receptors in lymphoid organ homeostasis

Curr Opin Immunol. 1999 Jun;11(3):319-25. doi: 10.1016/s0952-7915(99)80051-x.

Authors

S Jung¹, D R Littman

Affiliation

¹ Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA. jung@saturn.med.nyu.edu

PMID: 10375556
DOI: 10.1016/s0952-7915(99)80051-x

Abstract

Leukocytes respond to complex patterns of chemoattractant cytokine (chemokine) gradients that guide them to their destinations in secondary lymphoid organs. This directed movement of multiple cell types requires the choreographed expression of specific G-protein-coupled chemokine receptors and both positive and negative regulation of the signal transduction pathways emanating from them.

Publication types

Review

MeSH terms

Animals
Cell Movement
Dendritic Cells / immunology
Dendritic Cells / metabolism
GTP-Binding Proteins / metabolism
Homeostasis
Humans
Ligands
Lymphocytes / immunology
Lymphocytes / metabolism
Lymphoid Tissue / cytology
Lymphoid Tissue / immunology*
Lymphoid Tissue / metabolism
Models, Biological
Receptors, Chemokine / metabolism*
Signal Transduction

Substances

Ligands
Receptors, Chemokine
GTP-Binding Proteins