Abstract
A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Body Patterning*
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Chick Embryo / growth & development*
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Chick Embryo / metabolism
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Embryo, Mammalian / metabolism
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Embryonic Induction*
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Embryonic and Fetal Development*
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Fibroblast Growth Factor 8
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Fibroblast Growth Factors / genetics
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Fibroblast Growth Factors / physiology*
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Gene Expression Regulation, Developmental
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Heart / embryology
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Heart Defects, Congenital / embryology
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Hedgehog Proteins
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Homeobox Protein PITX2
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Homeodomain Proteins / genetics
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Homeodomain Proteins / physiology
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Left-Right Determination Factors
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Lung / abnormalities
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Lung / embryology
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Mesoderm / metabolism
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Mice
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Mutation
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Nodal Protein
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Nuclear Proteins*
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Paired Box Transcription Factors
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Proteins / genetics
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Proteins / physiology*
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Recombinant Proteins / metabolism
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Trans-Activators*
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Transcription Factors / genetics
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Transcription Factors / physiology
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Transforming Growth Factor beta / genetics
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Transforming Growth Factor beta / physiology
Substances
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Fgf8 protein, mouse
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Hedgehog Proteins
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Homeodomain Proteins
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Left-Right Determination Factors
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Nodal Protein
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Nodal protein, mouse
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Nuclear Proteins
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Paired Box Transcription Factors
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Proteins
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Recombinant Proteins
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Trans-Activators
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Transcription Factors
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Transforming Growth Factor beta
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homeobox protein PITX1
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homeobox protein PITX3
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Fibroblast Growth Factor 8
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Fibroblast Growth Factors