Lichenoid tissue reaction in porphyria cutanea tarda

Br J Dermatol. 1999 Jul;141(1):123-6. doi: 10.1046/j.1365-2133.1999.02932.x.

Abstract

We report a patient presenting with lichenoid plaques on exposed skin who had the metabolic features of porphyria cutanea tarda (PCT). Histology of lesional skin demonstrated a lichenoid inflammatory cell infiltrate in the upper dermis, while direct immunofluorescence revealed immunoreactive colloid bodies. Monochromator irradiation testing demonstrated photosensitivity in the visible spectrum consistent with porphyria. Solar-simulated irradiation induced a papular reaction with lichenoid histological changes. We propose that this atypical presentation of PCT may reflect a lichenoid tissue response to a porphyrin-mediated photochemical reaction.

Publication types

  • Case Reports

MeSH terms

  • Facial Dermatoses / pathology*
  • Hand Dermatoses / pathology*
  • Humans
  • Light / adverse effects
  • Male
  • Middle Aged
  • Porphyria Cutanea Tarda / pathology*
  • Skin / pathology*
  • Skin / radiation effects