New techniques: splenic artery embolization followed by intraarterial infusion chemotherapy for the treatment of pancreatic cancer

Hepatogastroenterology. 1999 May-Jun;46(27):2024-7.

Abstract

We present a new intraarterial infusion chemotherapy technique for the treatment of inoperable cancer in the body and tail of the pancreas. The spleen was embolized at its hilum with coils to infuse an anti-tumor agent selectively into the pancreatic parenchyma and a catheter was placed into the splenic artery and connected to the reservoir. 99mTc-macroaggregated albumin+diethylenetriaminepenta-acetic acid (MAA+DTPA) was injected into the reservoir and the body and tail of the pancreas were visualized on the image. For inoperable cancer in the body and tail of the pancreas, splenic artery embolization followed by the placement of a catheter into the splenic artery can deliver a highly concentrated anti-tumor agent to the tumor.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Chemoembolization, Therapeutic*
  • Cisplatin / administration & dosage
  • Diagnostic Imaging
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Fluorouracil / administration & dosage
  • Humans
  • Infusions, Intra-Arterial*
  • Male
  • Middle Aged
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / therapy*
  • Splenic Artery*

Substances

  • Cisplatin
  • Fluorouracil