Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands

A B Jones; J J Acton 3rd; A D Adams; W Yuen; E A Nichols; C D Schwartz; L S Wicker; J D Hermes

Tetrapeptide derived inhibitors of complexation of a class II MHC: fully unnatural ligands

Bioorg Med Chem Lett. 1999 Jul 19;9(14):2115-8.

Authors

A B Jones¹, J J Acton 3rd, A D Adams, W Yuen, E A Nichols, C D Schwartz, L S Wicker, J D Hermes

Affiliation

¹ Department of Basic Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

PMID: 10450992

Abstract

Tetrapeptide derived major histocompatability (MHC) II ligands have been developed that contain no unadulterated peptide bonds. These are the 'least peptidic' ligands for any MHC protein yet reported.

MeSH terms

Drug Design
Histocompatibility Antigens Class II / chemistry*
Histocompatibility Antigens Class II / drug effects
Histocompatibility Antigens Class II / metabolism*
Inhibitory Concentration 50
Lactams / chemistry
Ligands
Molecular Mimicry
Peptides / chemistry*
Structure-Activity Relationship

Substances

Histocompatibility Antigens Class II
Lactams
Ligands
Peptides