Expression pattern of macrophage migration inhibitory factor during embryogenesis

S Kobayashi; K Satomura; J M Levsky; T Sreenath; G J Wistow; I Semba; L Shum; H C Slavkin; A B Kulkarni

doi:10.1016/s0925-4773(99)00057-x

Expression pattern of macrophage migration inhibitory factor during embryogenesis

Mech Dev. 1999 Jun;84(1-2):153-6. doi: 10.1016/s0925-4773(99)00057-x.

Authors

S Kobayashi¹, K Satomura, J M Levsky, T Sreenath, G J Wistow, I Semba, L Shum, H C Slavkin, A B Kulkarni

Affiliation

¹ Functional Genomics Unit, Gene Targeting Facility, Bethesda, MD 20892, USA.

PMID: 10473131
DOI: 10.1016/s0925-4773(99)00057-x

Abstract

Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. Here we report a detailed characterization of MIF expression during mouse embryogenesis. The MIF expression pattern was found to parallel tissues specification and organogenesis.

MeSH terms

Animals
Animals, Newborn
Gene Expression Regulation, Developmental*
Liver / embryology
Liver / metabolism
Macrophage Migration-Inhibitory Factors / genetics*
Macrophage Migration-Inhibitory Factors / metabolism*
Male
Mesoderm / metabolism
Mice
Muscle Development
Muscle, Skeletal / embryology
Muscle, Skeletal / growth & development
Muscle, Skeletal / metabolism
Muscle, Smooth / embryology
Muscle, Smooth / growth & development
Muscle, Smooth / metabolism
Nervous System / embryology
Nervous System / metabolism
Testis / embryology
Testis / metabolism

Substances

Macrophage Migration-Inhibitory Factors