Kidney involvement in a 17-year-old boy with eosinophilic fasciitis

Clin Nephrol. 1999 Sep;52(3):183-7.

Abstract

Eosinophilic fasciitis (EF) is characterized by symmetrical scleroderma-like induration of skin over one or more distal extremities, peripheral eosinophilia, absence of Raynaud phenomenon and visceral involvement and a favourable response to systemically administered corticosteroids. Like other scleroderma-like disorders EF is rarely described in children. We report renal involvement in a 17-year-old boy with EF. Urinalysis disclosed proteinuria. Prior to corticosteroid therapy renal biopsy was performed which revealed ischemic collapse of glomerular capillaries and atrophy of tubules of the cortex. Electron-microscopic studies showed hyperplasia of the renin-producing epitheloid cells in the juxtaglomerular apparatus. Few other publications have depicted renal involvement in EF of quite different character. In these cases renal biopsy and histological classification is warranted because of prognostic and therapeutic implications.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Eosinophilia / complications*
  • Fasciitis / complications*
  • Humans
  • Kidney / pathology*
  • Kidney Diseases / etiology*
  • Kidney Diseases / pathology
  • Male