Circulating levels of soluble CD30 and other markers in colorectal cancer patients

J Med. 1999;30(1-2):111-21.

Abstract

In a search for new biologic serum tumor markers with prognostic value we evaluated the soluble form of the CD30 (sCD30), a marker of cells producing T helper 2 (Th2)-type cytokines, interleukin-1 receptor antagonist (IL-1ra), soluble interleukin-2 receptor (sIL-2R), soluble tumor necrosis factor -type I, -type II (sTNF-R55, -75) and immunosuppressive acidic protein (IAP) in patients, with advanced colorectal cancer. The data showed that abnormal levels of sCD30 were detected in eight (80.0%) out of ten patients. In contrast, sCD30 levels were not detected in healthy volunteers. The relationship between sCD30, sIL-2R and IAP were positively correlated. In contrast, sCD30 and IL-1ra were negatively correlated. These results suggested that IL-1ra may play a role, at least in part, to inhibit CD30 release, and sCD30 appears to be a new biologic serum tumor marker of possible use in the clinical setting of cancer patients.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Antigens, CD / blood
  • Biomarkers, Tumor / blood*
  • Colorectal Neoplasms / blood
  • Colorectal Neoplasms / diagnosis
  • Colorectal Neoplasms / immunology*
  • Female
  • Humans
  • Interleukin 1 Receptor Antagonist Protein
  • Ki-1 Antigen / blood*
  • Male
  • Middle Aged
  • Neoplasm Proteins / blood
  • Prognosis
  • Receptors, Interleukin-2 / blood
  • Receptors, Tumor Necrosis Factor / blood
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Reference Values
  • Sialoglycoproteins / blood

Substances

  • Antigens, CD
  • Biomarkers, Tumor
  • IL1RN protein, human
  • Interleukin 1 Receptor Antagonist Protein
  • Ki-1 Antigen
  • Neoplasm Proteins
  • Receptors, Interleukin-2
  • Receptors, Tumor Necrosis Factor
  • Receptors, Tumor Necrosis Factor, Type I
  • Receptors, Tumor Necrosis Factor, Type II
  • Sialoglycoproteins
  • immunosuppressive acidic protein