Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin

N Wernert; A Stanjek; S Kiriakidis; A Hügel; HC Jha; R Mazitschek; A Giannis

doi:10.1002/(sici)1521-3773(19991102)38:21<3228::aid-anie3228>3.0.co;2-8

Inhibition of Angiogenesis In Vivo by ets-1 Antisense Oligonucleotides-Inhibition of Ets-1 Transcription Factor Expression by the Antibiotic Fumagillin

Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3228-3231. doi: 10.1002/(sici)1521-3773(19991102)38:21<3228::aid-anie3228>3.0.co;2-8.

Authors

N Wernert¹, A Stanjek, S Kiriakidis, A Hügel, HC Jha, R Mazitschek, A Giannis

Affiliation

¹ Institut für Pathologie der Universität, Postfach 2120, D-53011 Bonn (Germany).

Abstract

The inhibition of angiogenesis in vivo as a result of the inhibition of Ets-1 transcription factor expression by the ets-1 phosphorothioate antisense oligodeoxynucleotide 5'-AGATCGACGGCCGCCTTCAT-3' has been proven by experiments with chicken embryos. Thus, participation of the Ets-1 transcription factor in the formation of new blood vessels in vivo has been demonstrated. Furthermore, it is shown that the angiostatic effect of the fungal metabolite and angiogenesis inhibitor fumagillin is mainly a result of its ability to inhibit Ets-1 expression.