Value of Ga-67 SPECT in monitoring the effects of therapy in invasive aspergillosis of the sphenoid sinus

Clin Nucl Med. 1999 Dec;24(12):938-41. doi: 10.1097/00003072-199912000-00006.

Abstract

Purpose: We report a case of invasive sphenoid sinus aspergillosis clinically presenting as a pituitary mass.

Methods: After exploration via the trans-sphenoidal approach and subsequent treatment with amphotericin-B, Ga-67 brain SPECT was performed twice to monitor the therapeutic effect.

Results: Three months after antifungal treatment, Ga-67 brain SPECT showed partial resolution of the lesion in the sella turcica region. The patient continued with fluconazole treatment for another 2 months and received another Ga-67 brain SPECT, which showed complete clearing of the previous lesion.

Conclusion: Ga-67 brain SPECT may play a potentially useful role in monitoring the therapeutic effect of treatment of invasive sphenoid sinus aspergillosis.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use*
  • Aspergillosis / diagnostic imaging
  • Aspergillosis / drug therapy*
  • Brain / diagnostic imaging
  • Diagnosis, Differential
  • Fluconazole / therapeutic use
  • Follow-Up Studies
  • Gallium Radioisotopes*
  • Humans
  • Male
  • Paranasal Sinus Diseases / diagnostic imaging
  • Paranasal Sinus Diseases / drug therapy
  • Paranasal Sinus Diseases / microbiology*
  • Pituitary Neoplasms / diagnosis
  • Radiopharmaceuticals*
  • Sella Turcica / diagnostic imaging
  • Sphenoid Sinus / diagnostic imaging
  • Sphenoid Sinus / drug effects
  • Sphenoid Sinus / microbiology*
  • Tomography, Emission-Computed, Single-Photon*
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Gallium Radioisotopes
  • Radiopharmaceuticals
  • Amphotericin B
  • Fluconazole