Chromosomal aberrations in lymphomas of the gastrointestinal tract

Leuk Lymphoma. 1999 Dec;36(1-2):25-32. doi: 10.3109/10428199909145946.

Abstract

B-cell lymphomas of the gastrointestinal (GI) tract have represented a field of extensive research ever since a close association was shown with chronic inflammatory processes such as Helicobacter pylori infection. Much evidence has accumulated to suggest that the mucosa-associated lymphoid tissue (MALT) induced by inflammation and autoimmune processes is the environment which gives rise to the small cell lymphomas of the GI tract (e.g. extranodal marginal B-cell lymphoma according to REAL). The small B-cell lymphoma may then progress to the large cell variants. Hence, B-cell lymphomas of the GI tract may present a model for lymphomagenesis and progression. In this review, recent cytogenetic data are discussed which yield new insights into the biology of gastrointestinal lymphomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosome Aberrations*
  • Gastrointestinal Neoplasms / genetics*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics
  • Lymphoma / genetics*
  • Lymphoma, B-Cell / genetics
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Precancerous Conditions / genetics