Localized bullous pemphigoid in a patient with B-cell lymphoma

South Med J. 1999 Dec;92(12):1220-2. doi: 10.1097/00007611-199912000-00019.

Abstract

Bullous pemphigoid (BP) is an immunobullous disease characterized by circulating IgG antibodies directed towards cutaneous basement zone antigens. We report the case of a patient who had BP localized to a stoma site. At initial examination, a nodule was noted on the temple, which proved to be a large cell lymphoma, B-cell phenotype. On Western immunoblot, the patient's serum showed circulating IgG antibodies reactive with the 230 kDa BP antigen and the 97 kDa linear IgA bullous dermatosis antigen. The co-incident onset of the two diseases suggest that this may represent a case of paraneoplastic BP.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Blotting, Western
  • Humans
  • Immunoglobulin G / blood
  • Lymphoma, B-Cell / complications*
  • Lymphoma, B-Cell / immunology
  • Male
  • Paraneoplastic Syndromes / etiology*
  • Paraneoplastic Syndromes / immunology
  • Pemphigoid, Bullous / etiology*
  • Pemphigoid, Bullous / immunology

Substances

  • Immunoglobulin G