Abstract
The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of beta-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.
MeSH terms
-
Adrenergic beta-Antagonists / metabolism
-
Animals
-
Binding Sites
-
Cerebral Cortex / drug effects*
-
Cyclic AMP / metabolism
-
Dose-Response Relationship, Drug
-
Hydroxydopamines / pharmacology*
-
Isoproterenol / pharmacology
-
Male
-
Rats
-
Receptors, Adrenergic / drug effects*
-
Receptors, Adrenergic, beta / drug effects*
-
Receptors, Adrenergic, beta / metabolism
Substances
-
Adrenergic beta-Antagonists
-
Hydroxydopamines
-
Receptors, Adrenergic
-
Receptors, Adrenergic, beta
-
Cyclic AMP
-
Isoproterenol