The bulk of the phosphorylation of human respiratory syncytial virus phosphoprotein is not essential but modulates viral RNA transcription and replication

J Gen Virol. 2000 Jan;81(Pt 1):129-33. doi: 10.1099/0022-1317-81-1-129.

Abstract

The ability of variants of the human respiratory syncytial virus (HRSV) phosphoprotein (P protein) to support RNA transcription and replication has been studied by using HRSV-based subgenomic replicons. The serine residues normally phosphorylated in P during HRSV infection have been replaced by other residues. The results indicate that the bulk of phosphorylation of P (98%) is not essential for viral RNA transcription or replication but that phosphorylation can modulate these processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • HN Protein*
  • Humans
  • Phosphoproteins / metabolism*
  • Phosphorylation
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism*
  • RNA, Viral / genetics
  • RNA, Viral / metabolism*
  • Replicon
  • Respiratory Syncytial Viruses / genetics
  • Respiratory Syncytial Viruses / metabolism*
  • Transcription, Genetic*
  • Viral Envelope Proteins
  • Viral Proteins / metabolism*
  • Virus Replication

Substances

  • HN Protein
  • Phosphoproteins
  • RNA, Messenger
  • RNA, Viral
  • Viral Envelope Proteins
  • Viral Proteins
  • attachment protein G