Abstract
Bacille Calmette-Guerin (BCG), Listeria monocytogenes, Salmonellae and Shigellae have shown promise as vaccine vectors in experimental animal models. Although disappointing results in humans and non-human primates stalled the development of this vaccination strategy, interest in this approach was reinvigorated recently by the development of bacterial DNA-vaccine-vectors. The purpose of this review is to highlight the strengths and weaknesses of bacterial vaccine vectors, and to discuss the future prospects of these vaccine delivery systems.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Antigens / genetics
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Antigens / immunology
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BCG Vaccine / genetics
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BCG Vaccine / immunology
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Bacterial Vaccines / genetics*
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Bacterial Vaccines / immunology*
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Bacterial Vaccines / therapeutic use
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Genetic Vectors*
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Humans
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Listeria monocytogenes / genetics
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Listeria monocytogenes / immunology
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Salmonella / genetics
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Salmonella / immunology
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Shigella / genetics
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Shigella / immunology
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Vaccines, Attenuated / genetics
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Vaccines, Attenuated / immunology
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Vaccines, Attenuated / therapeutic use
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Vaccines, Synthetic / genetics*
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Vaccines, Synthetic / immunology*
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Vaccines, Synthetic / therapeutic use
Substances
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Antigens
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BCG Vaccine
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Bacterial Vaccines
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Vaccines, Attenuated
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Vaccines, Synthetic