Abstract
We examined nine patients with histologically proven nasopharyngeal carcinoma (NPC), treated with radiotherapy, using dynamic susceptibility contrast MRI (DSC-MRI). In eight there was clinical evidence of radionecrosis of the temporal lobe, and one was examined for local recurrence in the nasopharynx. All patients had either high-signal finger-like or cystic lesions in the temporal lobes on T2-weighted images. Heterogeneous contrast enhancement occurred in all patients. Relative regional cerebral blood volume (rrCBV) mapping revealed marked hypoperfusion in all patients. One underwent bilateral temporal lobectomy and radionecrosis was confirmed histologically.
MeSH terms
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Adult
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Blood Volume / physiology
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Brain Diseases / diagnosis*
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Brain Diseases / pathology
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Brain Neoplasms / diagnosis
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Brain Neoplasms / secondary
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Carcinoma / radiotherapy
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Carcinoma / secondary
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Cerebrovascular Circulation / physiology
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Contrast Media
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Echo-Planar Imaging
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Female
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Gadolinium DTPA
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Humans
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Image Enhancement
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Image Processing, Computer-Assisted / methods
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Magnetic Resonance Imaging / methods*
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Male
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Middle Aged
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Nasopharyngeal Neoplasms / radiotherapy
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Necrosis
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Neoplasm Recurrence, Local / diagnosis
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Radiation Injuries / diagnosis*
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Temporal Lobe / blood supply
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Temporal Lobe / pathology
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Temporal Lobe / radiation effects*
Substances
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Contrast Media
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Gadolinium DTPA