Interaction with human immunodeficiency virus (HIV) type 2 predicts HIV type 1 genotype

Virology. 2000 Mar 15;268(2):402-10. doi: 10.1006/viro.2000.0192.

Abstract

In West Africa, India, and certain regions of Europe, both human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2) are known to cocirculate. To investigate the HIV-1 subtypes involved in dual HIV-1 and HIV-2 infections, we sequenced the envelope C2-V3 region from 29 dually infected female commercial sex workers from Senegal. The majority of women (23 of 29) were infected by HIV-1 subtype A. Within the HIV-1 subtype A sequences, 14 of 23 (60.8%) clustered with the West African associated A/G recombinant form (IbNG), and 9 of 23 (39.2%) formed a separate cluster distinct from the A/G IbNG. In contrast, in HIV-1 singly infected individuals, non-IbNG subtype A was found in only 13 of 98 (13.3%). Therefore, the lack of protection and/or interaction with HIV-2 was associated with a distinct HIV-1 A genotype. These results suggest differences in the biological properties of HIV-1 genotypes and their in vivo interaction with HIV-2.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Motifs / genetics
  • Amino Acid Sequence
  • Female
  • Genotype
  • HIV Infections / epidemiology
  • HIV Infections / genetics
  • HIV Infections / virology*
  • HIV-1 / genetics*
  • HIV-1 / physiology
  • HIV-2 / genetics
  • HIV-2 / physiology*
  • Humans
  • Molecular Sequence Data
  • Phylogeny
  • Senegal / epidemiology
  • Sequence Alignment