Management of patients with hypertension and diabetes mellitus: advances in the evidence for intensive treatment

Am J Med. 2000 Feb 15;108(3):238-45. doi: 10.1016/s0002-9343(99)00444-1.

Abstract

Diabetes mellitus is common in patients with hypertension, and greatly increases the risk of cardiovascular disease, including myocardial infarction, stroke, and peripheral vascular disease. "The pharmacologic therapy of patients with hypertension and diabetes has been surrounded by controversy because of concerns about the metabolic effects of several antihypertensive agents, as well as concerns about the safety of calcium antagonists. The objective of this review is to re-evaluate the management of diabetic patients with hypertension in light of the latest clinical trials. We also review the importance of intensive blood pressure control in these patients.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / drug effects
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / mortality
  • Clinical Trials as Topic
  • Diabetes Complications
  • Diabetes Mellitus / therapy*
  • Diabetic Nephropathies / prevention & control
  • Disease Management
  • Disease Progression
  • Humans
  • Hypertension / complications
  • Hypertension / drug therapy*
  • Outcome Assessment, Health Care
  • Risk

Substances

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents