H19 and IGF-2 allele-specific expression in hepatoblastoma

Br J Cancer. 2000 Feb;82(4):753-6. doi: 10.1054/bjoc.1999.0992.

Abstract

Patterns of allele-specific expression of H19 and insulin-like growth factor-2 (IGF-2) were examined in tissue obtained from 30 children diagnosed with hepatoblastoma. All informative tumours demonstrated monoallelic expression of H19. In contrast, variable patterns of allele-specific expression of IGF-2 were seen in tumours from children of different ages.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles*
  • Base Sequence
  • Child
  • Child, Preschool
  • DNA Primers
  • Female
  • Hepatoblastoma / genetics*
  • Humans
  • Infant
  • Infant, Newborn
  • Insulin-Like Growth Factor II / genetics*
  • Liver Neoplasms / genetics*
  • Male
  • Muscle Proteins / genetics*
  • RNA, Long Noncoding
  • RNA, Untranslated*

Substances

  • DNA Primers
  • H19 long non-coding RNA
  • Muscle Proteins
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Insulin-Like Growth Factor II