Eukaryotic translation termination factor gene (ETF1/eRF1) maps at D5S500 in a commonly deleted region of chromosome 5q31 in malignant myeloid diseases

Cytogenet Cell Genet. 2000;88(1-2):82-6. doi: 10.1159/000015491.

Abstract

The human genome contains four ETF1 (eukaryotic translation termination factor 1) homologous sequences, localized on chromosomes 5, 6, 7 and X, and corresponding to a functional gene on chromosome 5 and three processed pseudogenes on the other chromosomes. ETF1 genomic or cDNA probes were mapped by fluorescence in situ hybridization to 5q31, 6p21, 7q11 and Xp11.4-->p11.1. A microsatellite marker (D5S500) was identified in intron 7 of the functional ETF1 gene providing its exact position in the 5q31 band. Thus, the ETF1 gene is located in a 5q region which contains unidentified genes responsible for genetic or malignant disorders, and it might be considered as a candidate gene involved in the pathogenesis of these diseases.

MeSH terms

  • Acute Disease
  • Chromosome Deletion*
  • Chromosomes, Artificial, Yeast / genetics
  • Chromosomes, Human, Pair 5 / genetics*
  • Exons / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns / genetics
  • Leukemia, Myeloid / genetics*
  • Lymphocytes
  • Male
  • Microsatellite Repeats / genetics*
  • Peptide Termination Factors / genetics*
  • Physical Chromosome Mapping
  • Polymerase Chain Reaction
  • Pseudogenes / genetics*
  • Sequence Tagged Sites

Substances

  • ETF1 protein, human
  • Peptide Termination Factors