Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors

J Neurovirol. 2000 Feb;6(1):84-8. doi: 10.3109/13550280009006385.

Abstract

A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • AIDS Dementia Complex / drug therapy*
  • AIDS Dementia Complex / virology
  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Adult
  • Anti-HIV Agents / therapeutic use*
  • Female
  • Functional Laterality
  • HIV Protease Inhibitors / therapeutic use*
  • HIV Seropositivity
  • Hand / physiopathology
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Movement Disorders / drug therapy*
  • Movement Disorders / etiology
  • Neuropsychological Tests
  • Prospective Studies
  • Psychomotor Performance / drug effects
  • Viral Load

Substances

  • Anti-HIV Agents
  • HIV Protease Inhibitors