A new selective synthesis of the Ile-allo-Thr-Gly tripeptide fragment of lysobactin

Org Lett. 2000 Apr 20;2(8):1105-7. doi: 10.1021/ol005659o.

Abstract

[formula: see text] trans-Aziridine-2-carboxylic acid derivatives are useful intermediates for the synthesis of threonine or allo-threonine through ring expansion and SN2 displacement, respectively. We describe here the preparation of the Ile-allo-Thr-Gly 11 fragment of Lysobactin via the aziridine 9 intermediate.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Depsipeptides*
  • Magnetic Resonance Spectroscopy
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / chemistry
  • Peptide Fragments / chemical synthesis*
  • Protein Conformation

Substances

  • Depsipeptides
  • Oligopeptides
  • Peptide Fragments
  • katanosin B