(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

Bioorg Med Chem Lett. 2000 Jun 5;10(11):1241-4. doi: 10.1016/s0960-894x(00)00197-9.

Abstract

A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.

MeSH terms

  • Excitatory Amino Acid Agonists / pharmacology*
  • Glycine / analogs & derivatives*
  • Glycine / chemical synthesis
  • Glycine / chemistry
  • Glycine / pharmacology
  • Receptors, Metabotropic Glutamate / agonists*

Substances

  • 4-phosphonophenylglycine
  • Excitatory Amino Acid Agonists
  • Receptors, Metabotropic Glutamate
  • Glycine