Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

Cytokine. 2000 Jul;12(7):1100-3. doi: 10.1006/cyto.1999.0602.

Abstract

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recruitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Proteins*
  • Cell Movement / immunology
  • Chemokine CCL2 / biosynthesis*
  • Cholesterol / immunology
  • DNA-Binding Proteins / antagonists & inhibitors
  • DNA-Binding Proteins / immunology
  • Hydroxymethylglutaryl CoA Reductases / physiology*
  • Hypercholesterolemia / enzymology*
  • Hypercholesterolemia / immunology
  • Leukocytes / immunology*
  • Leukocytes / physiology
  • Male
  • Mice
  • Nuclear Proteins / antagonists & inhibitors
  • Nuclear Proteins / immunology
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors*

Substances

  • CCAAT-Enhancer-Binding Proteins
  • Chemokine CCL2
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Srebf1 protein, mouse
  • Sterol Regulatory Element Binding Protein 1
  • Transcription Factors
  • Cholesterol
  • Hydroxymethylglutaryl CoA Reductases