Dominant role of the C-terminal domain in the binding of apolipoprotein(a) to the protein core of proteoglycans and other members of the vascular matrix

Trends Cardiovasc Med. 1999 Oct;9(7):196-200. doi: 10.1016/s1050-1738(00)00020-7.

Abstract

The C-terminal domain of apolipoprotein(a) binds in vitro to the protein core of proteoglycans as well as fibrinogen and fibronectin, suggesting that this domain plays a role in anchoring lipoprotein(a) or free apolipoprotein(a) to the vascular subendothelial matrix.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Apolipoproteins A / chemistry*
  • Apolipoproteins A / metabolism*
  • Arteriosclerosis / metabolism
  • Binding Sites
  • Endothelium, Vascular / metabolism*
  • Extracellular Matrix / metabolism*
  • Fibrinogen / metabolism
  • Fibronectins / metabolism
  • Humans
  • Protein Binding
  • Protein Conformation
  • Protein Denaturation
  • Proteoglycans / chemistry*
  • Proteoglycans / metabolism*

Substances

  • Apolipoproteins A
  • Fibronectins
  • Proteoglycans
  • Fibrinogen