Abstract
Several genes are required during the early phases of liver specification, proliferation and differentiation. Here we report that Prox1 is required for hepatocyte migration. Loss of Prox1 leads to formation of a smaller liver with a reduced population of clustered hepatocytes surrounded by a laminin-rich basal membrane.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Movement / physiology*
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Homeodomain Proteins / genetics
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Homeodomain Proteins / metabolism*
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Liver / cytology*
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Liver / embryology
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Mice
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Prospero-Related Homeobox 1 Protein
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Tumor Suppressor Proteins
Substances
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Homeodomain Proteins
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Tumor Suppressor Proteins
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Prospero-Related Homeobox 1 Protein