Abstract
RXR class selectivity and RXR transcriptional activation activity compared to those for the retinoic acid receptor subtypes were enhanced on the 4-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenylethenyl)be nzoic acid scaffold and its 3-methyl analogue by replacing their 1,1-ethenyl bridge by a 1,1-(2-methylpropenyl) or cyclopropylidenylmethylene group.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cell Division / drug effects
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Humans
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Molecular Structure
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Receptors, Retinoic Acid / metabolism*
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Retinoid X Receptors
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Retinoids / chemistry
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Retinoids / metabolism*
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Retinoids / pharmacology
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Transcription Factors / metabolism*
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Tumor Cells, Cultured
Substances
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Receptors, Retinoic Acid
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Retinoid X Receptors
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Retinoids
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Transcription Factors