Abstract
We studied intrathecal IgG synthesis and autoantibody-secreting cells in 148 patients with possible onset symptoms of MS (POSMS) or clinically definite MS (CDMS). In POSMS intrathecal synthesis of IgG oligoclonal bands and abnormalities on T2-weighted magnetic resonance imaging were associated but the former were more prevalent. The cerebrospinal fluid (CSF) leukocyte count and the number of anti-protelipid protein antibody-secreting cells in cerebrospinal fluid (CSF) correlated with disease activity in POSMS. Intrathecal IgG synthesis levels and the number of anti-myelin basic protein antibody-secreting cells in CSF correlated with disease activity in CDMS. Our results support recent reports of pathogenetic heterogeneity and a pathogenetic role of the antibody response in MS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibody Specificity
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Autoantibodies / biosynthesis
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Autoantibodies / cerebrospinal fluid
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Autoantibodies / immunology*
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Autoantibodies / metabolism*
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B-Lymphocytes / immunology
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B-Lymphocytes / metabolism
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Female
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Humans
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Immunoglobulin G / biosynthesis*
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Immunoglobulin G / cerebrospinal fluid*
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Immunoglobulin G / immunology
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Immunoglobulin G / metabolism
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Leukocyte Count
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Multiple Sclerosis / cerebrospinal fluid*
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Multiple Sclerosis / immunology*
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Multiple Sclerosis / metabolism
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Multiple Sclerosis / physiopathology
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Myelin Basic Protein / cerebrospinal fluid
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Myelin Basic Protein / immunology
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Myelin Proteolipid Protein / immunology
Substances
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Autoantibodies
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Immunoglobulin G
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Myelin Basic Protein
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Myelin Proteolipid Protein