Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

P Diana; P Barraja; A Lauria; A M Almerico; G Dattolo; G Cirrincione

doi:10.1016/s0014-827x(00)00022-7

Pyrrolo[2,1-d][1,2,3,5]tetrazinones deaza analogues of temozolomide with potent antitumor activity

Farmaco. 2000 Mar;55(3):200-1. doi: 10.1016/s0014-827x(00)00022-7.

Authors

P Diana¹, P Barraja, A Lauria, A M Almerico, G Dattolo, G Cirrincione

Affiliation

¹ Dipartimento Farmacochimico Tossicologico e Biologico, Università di Palermo, Italy.

PMID: 10919082
DOI: 10.1016/s0014-827x(00)00022-7

Abstract

The title compounds, that hold the deaza skeleton of temozolomide, exhibited potent in vitro antiproliferative activity. An evaluation of such a biological activity indicates that the mode of action of these compounds differs from that of temozolomide and is also mechanistically unrelated to that of any known antitumor drug.

MeSH terms

Antineoplastic Agents, Alkylating / chemical synthesis*
Antineoplastic Agents, Alkylating / pharmacology
Dacarbazine / analogs & derivatives*
Dacarbazine / chemical synthesis
Dacarbazine / pharmacology
Heterocyclic Compounds, 2-Ring / chemical synthesis*
Heterocyclic Compounds, 2-Ring / pharmacology
Temozolomide

Substances

Antineoplastic Agents, Alkylating
Heterocyclic Compounds, 2-Ring
Dacarbazine
Temozolomide