Selective nuclear export of viral mRNAs in influenza-virus-infected cells

Trends Microbiol. 2000 Aug;8(8):376-83. doi: 10.1016/s0966-842x(00)01794-7.

Abstract

The NS1A protein of influenza A virus specifically inhibits the cellular machinery that processes the 3' ends of cellular pre-mRNAs by targeting two of the essential proteins of this machinery. Because the virus does not use this cellular machinery to synthesize the 3' poly(A) ends of viral mRNA, the nuclear export of cellular but not viral mRNAs is selectively inhibited.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Cell Nucleus / virology
  • Humans
  • Influenza A virus / metabolism*
  • Nuclear Proteins / metabolism
  • Poly(A)-Binding Proteins
  • RNA Processing, Post-Transcriptional
  • RNA, Messenger / metabolism*
  • RNA, Viral / metabolism*
  • RNA-Binding Proteins / metabolism
  • Viral Nonstructural Proteins / metabolism
  • mRNA Cleavage and Polyadenylation Factors

Substances

  • INS1 protein, influenza virus
  • Nuclear Proteins
  • Poly(A)-Binding Proteins
  • RNA, Messenger
  • RNA, Viral
  • RNA-Binding Proteins
  • Viral Nonstructural Proteins
  • mRNA Cleavage and Polyadenylation Factors