Abstract
Mutations in a 69-bp region of the rpoB gene associated with rifampin resistance (Rif(r)) in 100 isolates (82 Rif(r)) from three states of Brazil were studied. Twenty-one different kinds of mutations were identified in the Rif(r) isolates, and six new alleles are described.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antitubercular Agents / pharmacology*
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Brazil / epidemiology
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DNA-Directed RNA Polymerases / genetics*
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Drug Resistance, Microbial / genetics
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Drug Resistance, Multiple / genetics
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Genes, Bacterial
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Humans
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Microbial Sensitivity Tests
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Molecular Sequence Data
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Mutation*
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Mycobacterium tuberculosis / drug effects*
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Mycobacterium tuberculosis / enzymology
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Mycobacterium tuberculosis / genetics
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Sequence Analysis, DNA
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Tuberculosis, Pulmonary / epidemiology
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Tuberculosis, Pulmonary / microbiology*
Substances
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Antitubercular Agents
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DNA-Directed RNA Polymerases
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RNA polymerase beta subunit
Associated data
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GENBANK/AF143771
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GENBANK/AF146567
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GENBANK/AF147030
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GENBANK/AF147031
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GENBANK/AF147033
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GENBANK/AF147034