[Hemolytic anemia in a newborn after maternal treatment with nitrofurantoin at the end of pregnancy]

Arch Pediatr. 2000 Jul;7(7):745-7. doi: 10.1016/s0929-693x(00)80155-4.
[Article in French]

Abstract

Drug administration during the last trimester of pregnancy may have adverse effects for the newborn.

Case report: A hemolytic anemia occurred during the first hours of life in a full-term neonate whose mother had taken nitrofurantoin during the last month of pregnancy.

Conclusion: The immature enzymatic systems of the neonate are exposed to this adverse effect and justify the recommendation not to prescribe nitrofurantoin at the end of pregnancy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Anemia, Hemolytic / chemically induced*
  • Anti-Infective Agents, Urinary / administration & dosage
  • Anti-Infective Agents, Urinary / adverse effects*
  • Female
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases / chemically induced*
  • Male
  • Maternal-Fetal Exchange
  • Nitrofurantoin / administration & dosage
  • Nitrofurantoin / adverse effects*
  • Pregnancy
  • Pregnancy Complications, Infectious / drug therapy
  • Pregnancy Trimester, Third
  • Urinary Tract Infections / drug therapy

Substances

  • Anti-Infective Agents, Urinary
  • Nitrofurantoin