Association of t(9;11)-MLL AF9 and trisomy 8 in an AML-M5 preceded by pancytopenia

Cancer Genet Cytogenet. 2000 Jul 15;120(2):144-7. doi: 10.1016/s0165-4608(99)00260-5.

Abstract

The implication of MLL gene rearrangements in the prognosis of acute myeloblastic leukemia is an issue of considerable current interest. We report a case of a young man who initially presented with a pancytopenia and went on to develop a highly-aggressive acute myeloblastic leukemia. At this time, the karyotypic study revealed trisomy 8, a t(9;11) was demonstrated by fluorescence in situ hybridization (FISH) and the MLL/AF4 rearrangement by reverse transcriptase-polymerase chain reaction (RT-PCR).

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blotting, Southern
  • Chromosomes, Human, Pair 11 / genetics*
  • Chromosomes, Human, Pair 8 / genetics*
  • Chromosomes, Human, Pair 9 / genetics*
  • Cytogenetic Analysis
  • DNA, Neoplasm / genetics
  • DNA-Binding Proteins / genetics
  • Histone-Lysine N-Methyltransferase
  • Humans
  • In Situ Hybridization, Fluorescence
  • Karyotyping
  • Leukemia, Monocytic, Acute / genetics*
  • Leukemia, Monocytic, Acute / pathology
  • Male
  • Myeloid-Lymphoid Leukemia Protein
  • Nuclear Proteins / genetics
  • Oncogene Proteins, Fusion / genetics
  • Pancytopenia / genetics
  • Pancytopenia / pathology*
  • Proto-Oncogenes*
  • Transcription Factors*
  • Translocation, Genetic
  • Trisomy*

Substances

  • DNA, Neoplasm
  • DNA-Binding Proteins
  • KMT2A protein, human
  • MLLT3 protein, human
  • Nuclear Proteins
  • Oncogene Proteins, Fusion
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase