Use of saliva specimens for monitoring indinavir therapy in human immunodeficiency virus-infected patients

Antimicrob Agents Chemother. 2000 Sep;44(9):2572-4. doi: 10.1128/AAC.44.9.2572-2574.2000.

Abstract

Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% +/- 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Drug Monitoring*
  • Feasibility Studies
  • HIV Infections / blood*
  • HIV Infections / drug therapy
  • HIV Protease Inhibitors / blood
  • HIV Protease Inhibitors / metabolism*
  • HIV Protease Inhibitors / therapeutic use
  • Humans
  • Indinavir / blood
  • Indinavir / metabolism*
  • Indinavir / therapeutic use
  • Male
  • Saliva / metabolism*

Substances

  • HIV Protease Inhibitors
  • Indinavir