Abstract
Indinavir concentrations were determined in plasma and saliva over a random period of 4 h. On average, levels in saliva were 70% +/- 38% of the corresponding levels in plasma. These findings suggest that saliva might serve as an appropriate specimen for monitoring of plasma indinavir levels in patients treated with indinavir.
MeSH terms
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Adult
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Drug Monitoring*
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Feasibility Studies
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HIV Infections / blood*
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HIV Infections / drug therapy
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HIV Protease Inhibitors / blood
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HIV Protease Inhibitors / metabolism*
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HIV Protease Inhibitors / therapeutic use
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Humans
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Indinavir / blood
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Indinavir / metabolism*
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Indinavir / therapeutic use
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Male
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Saliva / metabolism*
Substances
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HIV Protease Inhibitors
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Indinavir