Objective: To evaluate subsequent pregnancy experience in patients following chemotherapy for malignant form of gestational trophoblastic disease.
Design: Retrospective clinical study.
Setting: Slovak Center of Trophoblastic Disease, Bratislava, Slovak Republic.
Methods: There were evaluated subsequent pregnancy experiences in 38 patients after chemotherapy for malignant form of gestational trophoblastic disease registered in Slovak center of gestational trophoblastic disease. Histological and cytogenetical analysis of all placentas after deliveries and material from curettage specimens after miscarriages, abortions and ectopic pregnancies were performed.
Results: 11 women conceived following successful chemotherapy of gestational trophoblastic disease became pregnant a total 19 times. Out of them there were 9 full-term deliveries, 2 spontaneous abortion, 1 ended in ectopic pregnancy and 7 pregnancies were terminated in therapeutic abortion. Cytogenetical analysis was successful in 7 to 10 reproductive losses with normal karyotype in all analysed cases.
Conclusion: Patients after successful chemotherapy of gestational trophoblastic disease have a normal reproductive outcome.