[Necrotizing enterocolitis: a historical and current review]

Med Klin (Munich). 2000 Aug 15;95(8):435-41. doi: 10.1007/s000630050003.
[Article in German]

Abstract

Enteritis necroticans, locally called "Darmbrand", is a severe and life threatening infectious disease which was epidemic in Northern Germany after World War II. Darmbrand had a limited appearance, occurring only for a few years. In Lübeck many cases were diagnosed in 1946/1948 and the book "Darmbrand, Enteritis necroticans" was published in 1949 by clinicians and pathologists. Enteritis necroticans is also known as a tropical cause of bloody diarrhea and is caused by Clostridium perfringens Type C (type beta-toxin). The disease is related to pig feasts in Papua New Guinea. Although necrotizing enterocolitis is now a rather rare disease we must be aware of the appearance of this fulminant entity. This paper represents a review on the historic and current aspects of enteritis necroticans and discusses the epidemiology, pathogenesis and treatment of this disease.

Publication types

  • English Abstract
  • Historical Article
  • Review

MeSH terms

  • Clostridium Infections / epidemiology
  • Clostridium Infections / history
  • Clostridium Infections / microbiology
  • Clostridium Infections / mortality
  • Clostridium perfringens / isolation & purification*
  • Disease Outbreaks* / history
  • Dysentery / etiology*
  • Dysentery / microbiology
  • Endotoxins / analysis
  • Enterocolitis, Necrotizing* / epidemiology
  • Enterocolitis, Necrotizing* / history
  • Enterocolitis, Necrotizing* / microbiology
  • Enterocolitis, Necrotizing* / mortality
  • Germany / epidemiology
  • History, 20th Century
  • Humans
  • Intestines / pathology
  • Starvation / complications*

Substances

  • Endotoxins