[Treatment of respiratory syncytial virus infections in immunocompromised hematological patients]

Ugeskr Laeger. 2000 Aug 28;162(35):4644-7.
[Article in Danish]

Abstract

Respiratory syncytial virus (RSV) accounts for considerable morbidity among infants and elderly, that are otherwise immunocompetent. Immunocompromised haematological patients--in particular bone marrow transplant (BMT) recipients with leukopenia--are at high risk for severe, usually fatal, RSV-pneumonia. No randomized, placebo-controlled studies of aerosolized ribavirin for BMT patients with RSV-pneumonia have been conducted, or can be anticipated. We summarize existing case reports providing circumstantial evidence in favour of an active diagnostic and early therapeutic approach to these patients.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Aerosols
  • Aged
  • Antiviral Agents / administration & dosage
  • Bone Marrow Transplantation / adverse effects
  • Bone Marrow Transplantation / immunology
  • Humans
  • Immunocompromised Host*
  • Infant
  • Leukopenia / immunology
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / immunology
  • Respiratory Syncytial Virus Infections / diagnosis
  • Respiratory Syncytial Virus Infections / drug therapy*
  • Respiratory Syncytial Virus Infections / immunology
  • Ribavirin / administration & dosage
  • Risk Factors

Substances

  • Aerosols
  • Antiviral Agents
  • Ribavirin