Abstract
Eleven cyclic diarylheptanoids were screened as potential antitumor promoters by examining the ability of the compounds to inhibit Epstein-Barr virus early antigen activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. 13-Oxomyricanol and myricanone showed the highest activity and also exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. These data suggest that certain diarylheptanoids might be valuable antitumor promoters and/or chemopreventors.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / toxicity
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Animals
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Carcinogens / toxicity
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Diarylheptanoids*
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Dose-Response Relationship, Drug
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Female
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Herpesvirus 4, Human / drug effects*
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Humans
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Hydrocarbons, Cyclic / chemistry
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Hydrocarbons, Cyclic / pharmacology
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Mice
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Mice, Inbred ICR
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Papilloma / chemically induced
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Papilloma / prevention & control
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Skin Neoplasms / chemically induced
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Skin Neoplasms / prevention & control*
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Specific Pathogen-Free Organisms
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Terpenes / pharmacology
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Tetradecanoylphorbol Acetate / pharmacology
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Time Factors
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Tumor Cells, Cultured
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Virus Activation / drug effects
Substances
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Antineoplastic Agents
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Carcinogens
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Diarylheptanoids
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Hydrocarbons, Cyclic
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Terpenes
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myricanone
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9,10-Dimethyl-1,2-benzanthracene
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Tetradecanoylphorbol Acetate