Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

W He; M Cik; A Lesage; I Van der Linden; N De Kimpe; G Appendino; J Bracke; S G Mathenge; F P Mudida; J E Leysen; L Van Puyvelde

doi:10.1021/np000249u

Kirkinine, a new daphnane orthoester with potent neurotrophic activity from Synaptolepis kirkii

J Nat Prod. 2000 Sep;63(9):1185-7. doi: 10.1021/np000249u.

Authors

W He¹, M Cik, A Lesage, I Van der Linden, N De Kimpe, G Appendino, J Bracke, S G Mathenge, F P Mudida, J E Leysen, L Van Puyvelde

Affiliation

¹ Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, Ghent University, Coupure Links 653, B-9000 Ghent, Belgium.

PMID: 11000015
DOI: 10.1021/np000249u

Abstract

The bioassay-guided fractionation of a dichloromethane extract from the roots of Synaptolepis kirkii using neuronal viability as a model allowed the isolation of the new daphnane orthoester kirkinine (1a) as a powerful neurotrophic constituent.

MeSH terms

Animals
Cell Survival / drug effects
Chick Embryo
Diterpenes*
Esters
Euphorbiaceae / chemistry*
Ganglia, Spinal / cytology
Ganglia, Spinal / drug effects*
In Vitro Techniques
Neurons / drug effects*
Spectrum Analysis
Terpenes / chemistry*
Terpenes / pharmacology
Triterpenes / chemistry
Triterpenes / pharmacology*

Substances

Diterpenes
Esters
Terpenes
Triterpenes
kirkinine
mezerein