Abstract
Glycosylation, sulfation and phosphorylation of proteins, proteoglycans and lipids occur in the lumen of the Golgi apparatus. The nucleotide substrates of these reactions must be first transported from the cytosol into the Golgi lumen by specific transporters. The topology and structure of these hydrophobic, multi-transmembrane-spanning proteins are beginning to be understood.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Carrier Proteins / chemistry
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Carrier Proteins / metabolism*
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Cloning, Molecular
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Golgi Apparatus / metabolism*
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Molecular Sequence Data
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Nucleoside Transport Proteins
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Sequence Homology, Amino Acid
Substances
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Carrier Proteins
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Membrane Proteins
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Nucleoside Transport Proteins